The Spitzer-IRAC/MIPS Extragalactic survey (SIMES) in the South Ecliptic Pole field (SEP) covers an area of 7.74 sq. deg to a depth of ~5.80 microJy (3sigma) at 3.6 microns and 5.25 microJy at 4.5 microns. The 90% and 50% completeness limits are at 14 and 9 microJy, respectively. The multiwavelength catalog includes the WFI-Rc, MIPS-24 micron, SPIRE 250, 350 and 500 micron fluxes of the counterparts that were identified by searching for the closest neighbor. <P />The indicator P quantifies the reliability of each association (example, for P1: SPIRE to MIPS) considering both the distance between the SPIRE source and the closest MIPS association and the presence of further possible MIPS associations in the MIPS-SPIRE searching radius. <P />For bands other than IRAC 3.6 microns, a null flux means no coverage in that band, while a flux of zero means that the position is covered in that band but the source is not detected. <P />(1 data file).