High performance 3D CZT spectro-imager for BNCT-SPECT: preliminary characterization
Date Issued
2018
Author(s)
Fatemi, S.
•
Abbene, L.
•
Principato, F.
•
Buttacavoli, A.
•
•
•
•
Zambelli, N.
•
Benassi, G.
•
Bettelli, M.
•
Zanettini, S.
•
Zappettini, A.
•
Bortolussi, S.
•
Magni, C.
•
Postuma, I.
•
Altieri, S.
•
Protti, N.
Abstract
The National Institute of Nuclear Physics (INFN) is supporting the 3CaTS project with the aim of developing a new Single Photon Emission Computed Tomography (SPECT) system for real time 10 B therapeutic dose monitoring in the binary experimental hadron therapy called Boron Neutron Capture Therapy (BNCT). BNCT is a highly selective tumour treatment based on the neutron capture reaction 10 B(n,α) 7 Li. The secondary particles have a high LET with ranges in tissues of the order of 10 μm (thus less than the mean cell diameter of few tens μm). Targeting the 10 B delivery towards cancer, the released energy lethally damages only the malignant cells sparing the normal tissues, thus enabling a cell-level selective treatment. To properly exploit this selectivity it is mandatory to know the 10 B spatial distribution inside patients body during neutron irradiation. This can be achieved by detecting the 478 keV γ ray emitted in the 94% of 10 B capture reactions by a SPECT system. A 3D CZT drift strip detector with a sensitive volume of 20x20x5 mm 3 was developed, able to perform high-resolution X-ray and γ ray spectroscopic imaging (10-1000 keV). The detector signals are analysed by a custom digital multi-channel electronics, based on two pipelined fast and slow analysis, able to perform multi-parameter analysis and fine temporal coincidences (<; 20 ns). Energy resolution of 3.3% (4 keV) and 2% (13 keV) FWHM was measured, with uncollimated sources and no corrections, at 122 keV and 662 keV, respectively.
Coverage
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference Proceedings (NSS/MIC)
Start page
1
Conferenece
2018 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
Conferenece place
Sydney, Australia,
Conferenece date
10-17 November, 2018
Issn Identifier
1082-3654
Rights
open.access
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